Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults | NEJM


Abstract Background Vitamin D supplements are widely recommended for bone health in the general population, but data on whether they prevent fractures have been inconsistent. Methods In an ancillary study of the Vitamin D and Omega-3 Trial (VITAL), we tested whether supplemental vitamin D3 would result in a lower risk of fractures than placebo. VITAL was a two-by-two factorial, randomized, con...

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